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Gábor Mező Selected Research

LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)

5/2022Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates.
10/2019Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers.
9/2019Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
9/2019Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells.
1/2018Drug targeting to decrease cardiotoxicity - determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells.
1/2018Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin-GnRH-III conjugates developed for targeted drug delivery.
1/2018Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
1/2017In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues.
1/2016Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice.
10/2012Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates.
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Gábor Mező Research Topics

Disease

36Neoplasms (Cancer)
05/2022 - 01/2012
9Colonic Neoplasms (Colon Cancer)
06/2020 - 06/2012
5Breast Neoplasms (Breast Cancer)
01/2020 - 01/2012
4Neoplasm Metastasis (Metastasis)
01/2021 - 03/2015
4Prostatic Neoplasms (Prostate Cancer)
10/2019 - 01/2012
4Colorectal Neoplasms (Colorectal Cancer)
09/2019 - 01/2016
3Melanoma (Melanoma, Malignant)
01/2021 - 02/2015
3Carcinoma (Carcinomatosis)
10/2019 - 01/2014
2Pancreatic Neoplasms (Pancreatic Cancer)
05/2022 - 06/2020
2Tics (Tic)
09/2019 - 11/2018
2Fibrosarcoma
01/2018 - 01/2017
1Ovarian Neoplasms (Ovarian Cancer)
05/2022
1Diabetic Retinopathy (Retinopathy, Diabetic)
03/2022
1Ischemia
03/2022
1Reperfusion Injury
03/2022
1Thrombosis (Thrombus)
01/2022
1COVID-19
01/2022
1Kaposi Sarcoma (Kaposi's Sarcoma)
01/2021
1Hepatocellular Carcinoma (Hepatoma)
01/2020
1Hypoxia (Hypoxemia)
01/2020
1Squamous Cell Carcinoma of Head and Neck
10/2019
1Head and Neck Neoplasms (Head and Neck Cancer)
10/2019
1Necrosis
09/2018
1Cardiomyopathies (Cardiomyopathy)
01/2018
1Cardiotoxicity
01/2018
1Mesoblastic Nephroma (Congenital Mesoblastic Nephroma)
03/2015
1Leukemia
01/2013
1Tuberculosis (Tuberculoses)
05/2012

Drug/Important Bio-Agent (IBA)

17Peptides (Polypeptides)IBA
08/2021 - 06/2012
15gonadotropin-releasing hormone-IIIIBA
05/2022 - 01/2012
14Daunorubicin (Cerubidine)FDA LinkGeneric
05/2022 - 06/2012
13Gonadotropin-Releasing Hormone (GnRH)FDA Link
05/2022 - 01/2013
11Pharmaceutical PreparationsIBA
05/2022 - 06/2012
11LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA
05/2022 - 01/2012
7Cytostatic AgentsIBA
01/2018 - 01/2012
6CD13 Antigens (Alanine Aminopeptidase)IBA
03/2022 - 03/2015
6IntegrinsIBA
01/2021 - 03/2015
4Protein Isoforms (Isoforms)IBA
07/2020 - 01/2017
4Biological ProductsIBA
06/2020 - 05/2015
4Hormones (Hormone)IBA
01/2016 - 01/2012
368Ga-NOTA-c(NGR)IBA
03/2022 - 01/2020
3Antineoplastic Agents (Antineoplastics)IBA
02/2021 - 01/2013
3RadiopharmaceuticalsIBA
01/2021 - 01/2020
3NGR peptideIBA
01/2021 - 01/2017
2Anti-Bacterial Agents (Antibiotics)IBA
02/2021 - 05/2012
2asparagine-glycine-arginineIBA
11/2020 - 01/2017
2hydroxide ionIBA
07/2020 - 06/2020
21- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA
01/2020 - 03/2015
2Proteins (Proteins, Gene)FDA Link
09/2019 - 01/2014
2LigandsIBA
11/2018 - 09/2018
2Peptide Hormones (Polypeptide Hormones)IBA
01/2018 - 04/2013
2Methotrexate (Mexate)FDA LinkGeneric
01/2018 - 06/2012
2Volatile Fatty AcidsIBA
01/2018 - 10/2012
2His(5)-Trp(7)-Tyr(8)- LHRHIBA
01/2017 - 05/2015
2thiazolyl blueIBA
04/2013 - 06/2012
1Paclitaxel (Taxol)FDA LinkGeneric
05/2022
1Cathepsin BIBA
05/2022
1DipeptidesIBA
05/2022
14-azidobenzylcarazolol (pABC)IBA
05/2022
1serum P-component (CIt)IBA
05/2022
1DiarylheptanoidsIBA
01/2022
1Dosage Forms (Dosage Form)IBA
01/2022
1AnthracyclinesIBA
02/2021
1ubenimexIBA
01/2021
1Cyclic PeptidesIBA
01/2021
1actinoninIBA
01/2021
1polypeptide CIBA
11/2020
11,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA
11/2020
1Epidermal Growth Factor (EGF)IBA
01/2020
1Staphylococcal Protein A (Protein A)IBA
01/2020
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2020
1Photosensitizing Agents (Photosensitizers)IBA
10/2019
1protoporphyrin IXIBA
10/2019
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
09/2019
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2019
1Estrogen ReceptorsIBA
11/2018
1Reactive Oxygen Species (Oxygen Radicals)IBA
09/2018
1TIC10 compoundIBA
09/2018
1Cytotoxins (Cytolysins)IBA
01/2018
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2018
1Fluorescein-5-isothiocyanate (FITC)IBA
01/2017
1Butyric Acid (Butanoic Acid)IBA
01/2016
1OximesIBA
01/2016
1Acetic Acid (Vinegar)FDA LinkGeneric
01/2016
1Annexin A5IBA
05/2015
1dUTP pyrophosphataseIBA
05/2012
1Antitubercular AgentsIBA
05/2012
1EnzymesIBA
05/2012

Therapy/Procedure

18Therapeutics
05/2022 - 05/2012
4Drug Therapy (Chemotherapy)
01/2016 - 10/2012
2Intravenous Injections
11/2020 - 01/2020
1Ligation
03/2022
1Subcutaneous Injections
11/2020
1Photochemotherapy (Photodynamic Therapy)
10/2019
1Transplantation
03/2015
1Aftercare (After-Treatment)
01/2014